Clean Architecture enforces separation of concerns through distinct layers with dependencies pointing inward, including domain, application, infrastructure, and presentation layers. For Flutter applications, it guides organization using feature-first structures, state management with flutter_bloc, immutable states with freezed, and functional error handling. For Go backends, it details layer separation, interface-driven development, project structuring, and table-driven unit testing. Reach for this skill when building or refactoring applications to adhere to strict clean architecture principles in Flutter and Go.